laboratoire de physique statistique
 
 
laboratoire de physique statistique

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Dalila AJJAJI 


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P U B L I C A T I O N S



 
2016
N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes - Ajjaji, Dalila and Richard, Charles-Adrien and Mazerat, Sandra and Chevalier, Christophe and Vidic, Jasmina
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 47727-32 (2016) 
LPS


Abstract : PB1-F2 protein is a factor of virulence of influenza A viruses which increases the mortality and morbidity associated with infection. Most seasonal H1N1 Influenza A viruses express nowadays a truncated version of PB1-F2. Here we show that truncation of PB1-F2 modified supramolecular organization of the protein in a membrane-mimicking environment In addition, full-length PB1-F2(1-90) and C-terminal PB1-F2 domain (53-90), efficiently permeabilized various anionic liposomes while N-terminal domain PB1-F2(1-52) only lysed cholesterol and cardiolipin containing lipid bilayers. These findings suggest that the truncation of PB1-F2 may impact the pathogenicity of a given virus strain. (C) 2016 Published by Elsevier Inc.