laboratoire de physique statistique
 
 
laboratoire de physique statistique

Publications

Rechercher
Martine BEN AMAR 


PHYSICS OF LIFE REVIEWS 


2
P U B L I C A T I O N S

S E L E C T I O N N E R
P A R M I :


 
2016
Multiscale modeling of fibrosis - What's next? Reply to Comments on ``Towards a unified approach in the modeling of fibrosis: A review with research perspective'' by Martine Ben Amar and Carlo Bianca - Ben Amar, Martine and Bianca, Carlo
PHYSICS OF LIFE REVIEWS 17118-123 (2016) 
LPS
Towards a unified approach in the modeling of fibrosis: A review with research perspectives - Ben Amar, Martine and Bianca, Carlo
PHYSICS OF LIFE REVIEWS 1761-85 (2016) 
LPS


Abstract : Pathological fibrosis is the result of a failure in the wound healing process. The comprehension and the related modeling of the different mechanisms that trigger fibrosis are a challenge of many researchers that work in the field of medicine and biology. The modern scientific analysis of a phenomenon generally consists of three major approaches: theoretical, experimental, and computational. Different theoretical tools coming from mathematics and physics have been proposed for the modeling of the physiological and pathological fibrosis. However a complete framework is missing and the development of a general theory is required. This review aims at finding a unified approach in the modeling of fibrosis diseases that takes into account the different phenomena occurring at each level: molecular, cellular and tissue. Specifically by means of a critical analysis of the different models that have been proposed in the mathematical, computational and physical biology, from molecular to tissue scales, a multiscale approach is proposed, an approach that has been strongly recommended by top level biologists in the past decades. (C) 2016 Elsevier B.V. All rights reserved.