laboratoire de physique statistique
 
 
laboratoire de physique statistique

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CHEMICAL SOCIETY REVIEWS 


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P U B L I C A T I O N S



 
2014
The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems - Sterpone, Fabio and Melchionna, Simone and Tuffery, Pierre and Pasquali, Samuela and Mousseau, Normand and Cragnolini, Tristan and Chebaro, Yassmine and St-Pierre, Jean-Francois and Kalimeri, Maria and Barducci, Alessandro and Laurin, Yoann and Tek, Alex and Baaden, Marc and Phuong Hoang Nguyen and Derreumaux, Philippe
CHEMICAL SOCIETY REVIEWS 434871-4893 (2014)

Abstract : The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA-RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.