laboratoire de physique statistique
 
 
laboratoire de physique statistique

Publications

Rechercher
2014 


GENETICS 


1
P U B L I C A T I O N S



 
2014
Six Homeoproteins and a Iinc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype - Sakakibara, Iori and Santolini, Marc and Ferry, Arnaud and Hakim, Vincent and Maire, Pascal
PLOS GENETICS 10 (2014)

Abstract : Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.