laboratoire de physique statistique
 
 
laboratoire de physique statistique

Publications

Rechercher
ORGANIC LETTERS 


1
P U B L I C A T I O N S



 
2008
Alcohol uncaging with fluorescence reporting: Evaluation of o-acetoxyphenyl methyloxazolone precursors - Gagey, Nathalie and Emond, Matthieu and Neveu, Pierre and Benbrahim, Chouaha and Goetz, Bernard and Aujard, Isabelle and Baudin, Jean-Bernard and Jullien, Ludovic
ORGANIC LETTERS 102341-2344 (2008)

Abstract : This paper evaluates a series of photolabile protecting groups with built-in fluorescence reporting. They rely on readily available o-acetoxyphenyl methyloxazolones as activated precursors. Alcohol substrates are easily caged. The resulting photoactivable esters exhibit large one- and two-photon uncaging cross sections. The alcohol substrates are quantitatively released in a 1:1 molar ratio with a strongly fluorescent coumarin coproduct that serves as a reporter to quantify substrate delivery.