Francis CorsonCNRS researcher
Laboratoire de Physique de l'Ecole Normale Supérieure
24, rue Lhomond
75231 Paris Cedex 05
Center for Studies in Physics and Biology
The Rockefeller University
corson at phys.ens.fr
I am a theoretician working at the interface between physics and developmental biology (patterning and morphogenesis), in close collaboration with experimentalists. My contribution includes theory and modeling (with a preference for simple/coarse-grained models, which I find most illuminating), along with the development of image/data analysis tools, to work towards a quantitative, dynamical picture of development.
Current projects include:
- neural patterning in Drosophila, with the group of François Schweisguth at the Pasteur Institute;
- early morphogenesis of the amniote embryo, with the group of Jérôme Gros, also in Pasteur.
A common thread in several projects, that is fruitfully approached through a combination of theory and experiments, is the role for self-organization in development.
Self-organized tissue mechanics underlie embryonic regulation
P. Caldarelli, A. Chamolly, O. Alegria-Prévot, J. Gros*, F. Corson*, bioRxiv
A tensile ring drives tissue flows to shape the gastrulating amniote embryo
M. Saadaoui, D. Rocancourt, J. Roussel, F. Corson*, J. Gros*
Science, 367, 453–458 (2020) link preprint
Self-organization in pattern formation
F. Schweisguth, F. Corson, Dev Cell, 49, 659-677 (2019) link
Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila
F. Corson, L. Couturier, H. Rouault, K. Mazouni, F. Schweisguth
Science, 356, eaai7407 (2017) link
Gene-free methodology for cell fate dynamics during development
F. Corson, E. Siggia, eLife, 6, e30743 (2017) link pdf